GUO, Weilong

PhD, Bioinformatics
Associate Professor
Department of Crop Genomics and Bioinformatics
China Agricultural University
No 2 West YuanMingYuan Road
Haidian District, Beijing
China, 100094
Email :
or      (alternative)

Education & Research [top]

Since 2017.12 Associate Professer

• Wheat Genetics & Genomics Center (WGGC)
• Department of Crop Genomics and Bioinformatics
• College of Agronomy and Biotechnology
• China Agricultural University

2016.06-2017.12 Lecturer

• Wheat Genetics & Genomics Lab
• Department of Crop Genomics and Bioinformatics
• College of Agronomy and Biotechnology
• China Agricultural University

2014.07-2016.06 POSTDOC

• School of Life Sciences
• Center of Life Sciences
• Peking University

2009.9-2014.07 PH.D.

• Department of Automation, Tsinghua University
• Bioinformatics Division & Center for System and Synthetic Biology, Tsinghua National Laboratory for Information Science & Technology
• Supervisor: Prof. Michael Q. ZHANG
  * Initially recruited as student under Chair Professor Team

2012.10-2013.10 Visiting student

• MCDB department, UCLA
• Visiting Graduate Researcher (CSC scholarship)
• Supervisor: Prof. Matteo Pellegrini

2005.9-2009.7 B.E.

• School of Software Engineering
• Beijing University of Posts and Telecommunications (BUPT)
• Major : Software Engineering

Selected Publications   [top]

     (* First/Co-first Author;   # Corresponding/Co-corresponding author)

• (15) Zihao Wang, Lingfeng Miao, Yongming Chen, Huiru Peng, Zhongfu Ni, Qixin Sun, Weilong Guo #. (2023) Deciphering the evolution and complexity of wheat germplasm from a genomic perspective , Journal of Genetics and Genomics, 50(11):846-860. (# Corresponding Authors)
  DOI:doi:10.1016/j.jgg.2023.08.002
  (Review)

• (14) Zhaoheng Zhang *, Ruijie Zhang *, Fengfan Meng, Yongming Chen, Wenxi Wang, Kai Yang, Yujiao Gao, Mingming Xin, Jinkun Du, Zhaorong Hu, Zhongfu Ni, Qixin Sun, Weilong Guo #, Yingyin Yao #. (2023) A comprehensive atlas of long non-coding RNAs provides insight into grain development in wheat , Seed Biology, 2:12. (# Corresponding Authors)
  DOI:doi:10.48130/SeedBio-2023-0012
  [Datbase: wLNCdb]

• (13) Yongming Chen, Yiwen Guo, Xiaoming Xie, Zihao Wang, Lingfeng Miao, Zhengzhao Yang, Yuannian Jiao, Chaojie Xie, Jie Liu, Zhaorong Hu, Mingming Xin, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng #, Weilong Guo #. (2023) Pangenome-based trajectories of intracellular gene transfers in Poaceae unveil high cumulation in Triticeae , Plant Physiology, 193(1):578-594. (# Corresponding Authors)
  DOI:doi:10.1093/plphys/kiad319
  [Software: IGTminer]
  [Datbase: pNOGmap]

• (12) Dawa Dondup *, Yang Yang *, Dongdong Xu *, Lhundrup Namgyal, Zihao Wang, Xia Shen, Tsechoe Dorji, Nyima kyi, Lhakpa Drolma, Liyun Gao, Zhuo Ga, Zha Sang, Zhuo Ga, Wang Mu, Pubu Zhuoma, Xiongnu Taba, Guocheng Jiao, Wenhua Liao, Yawei Tang, Xingquan Zeng, Zhaxi Luobu, Yufeng Wu, Chunchao Wang, Jing Zhang, Zengjun Qi #, Weilong Guo #, Ganggang Guo #. (2023) Genome diversity and highland-adaptative variation in Tibet barley landrace population of China , Frontiers in Plant Science, 14:1189642. (# Corresponding Authors; * Joint First Authors)
  DOI:doi:10.3389/fpls.2023.1189642

• (11) Zhichao Yu *, Yongming Chen *, Yong Zhou *, Yulu Zhang, Mengyuan Li, Yidan Ouyang, Dmytro Chebotarov, Ramil Mauleon, Hu Zhao, Weibo Xie, Kenneth L. McNally, Rod A. Wing #, Weilong Guo #, Jianwei Zhang #. (2023) Rice Gene Index: A comprehensive pan-genome database for comparative and functional genomics of Asian rice , Molecular Plant, 16(5):798-801. (# Corresponding Authors; * Joint First Authors)
  DOI:doi:10.1016/j.molp.2023.03.012

• (10) Yongming Chen *, Yiwen Guo *, Panfeng Guan, Yongfa Wang, Xiaobo Wang, Zihao Wang, Zhen Qin, Shengwei Ma, Mingming Xin, Zhaorong Hu, Yingyin Yao, Zhongfu Ni, Qixin Sun, Weilong Guo #, Huiru Peng #. (2022) A wheat integrative regulatory network from large-scale complementary functional datasets enables trait-associated gene discovery for crop improvement, Molecular Plant, 16(2):393-414. (# Corresponding Authors; * Joint First Authors)
  DOI:10.1016/j.molp.2022.12.019
  [Database: wGRN]

• (9) Zihao Wang, Wenxi Wang, Xiaoming Xie, Yongfa Wang, Zhengzhao Yang, Huiru Peng, Mingming Xin, Yingyin Yao, Zhaorong Hu, Jie Liu, Zhenqi Su, Chaojie Xie, Baoyun Li, Zhongfu Ni, Qixin Sun #, Weilong Guo #. (2022) Dispersed emergence and protracted domestication of polyploid wheat uncovered by mosaic ancestral haploblock inference, Nature Communications, 13:3891. (# Co-corresponding Author)
  DOI:doi:10.1038/s41467-022-31581-0
  [Software: IntroBlocker]
  [Behind The Paper: What makes wheat a successful major crop?]

• (8) Zhengzhao Yang *, Zihao Wang *, Wenxi Wang *, Xiaoming Xie, Lingling Chai, Xiaobo Wang, Xibo Feng, Jinghui Li, Huiru Peng, Zhenqi Su, Mingshan You, Yingyin Yao, Mingming Xin, Zhaorong Hu, Jie Liu, Rongqi Liang, Zhongfu Ni, Qixin Sun, Weilong Guo #. (2022) ggComp enables dissection of germplasm resources and construction of a multiscale germplasm network in wheat, Plant Physiology, 188(4):1950-1965. (# Corresponding Author; * Joint First Authors)
  DOI:doi:10.1093/plphys/kiac029
  [Software: ggComp]
  [Database: WheatCompDB]

• (7) Yongming Chen, Wanjun Song, Xiaoming Xie, Zihao Wang, Panfeng Guan, Huiru Peng, Yuannian Jiao, Zhongfu Ni, Qixin Sun, Weilong Guo #. (2020) A Collinearity-incorporating Homology Inference Strategy for Connecting Emerging Assemblies in Triticeae Tribe as a Pilot Practice in the Plant Pangenomic Era, Molecular Plant , 13(12):1694-1708. (# Corresponding Author)
  DOI:doi:10.1016/j.molp.2020.09.019
  [Featured Article: (On The Cover) ]
  [Software: GeneTribe]
  [Database: Triticeae-GeneTribe / TGT]

• (6) Weilong Guo *, Mingming Xin *, Zihao Wang *, Yingyin Yao, Zhaorong Hu, Wanjun Song, Kuohai Yu, Yongming Chen, Xiaobo Wang, Panfeng Guan, Rudi Appels, Huiru Peng #, Zhongfu Ni #, Qixin Sun #. (2020) Origin and adaptation to high altitude of Tibetan semi-wild wheat, Nature Communications , 11:5085. (# Corresponding Authors; * Joint First Authors)
  DOI:doi:10.1038/s41467-020-18738-5
  [Resource Homepage: Zang817_Genome]
  [SnpHub server: SnpHub-NC20]

• (5) Wenxi Wang *, Zihao Wang *, Xintong Li, Zhongfu Ni, Zhaorong Hu, Mingming Xin, Huiru Peng, Yingyin Yao, Qixin Sun, Weilong Guo #. (2020) SnpHub: an easy-to-set-up web server framework for exploring large-scale genomic variation data in the post-genomic era with applications in wheat, GigaScience , 9(6):giaa060. (# Corresponding Author; * Joint First Authors)
  DOI:doi:10.1093/gigascience/giaa060
  [Software: SnpHub]
  [Servers: Wheat-SnpHub-Portal]

• (4) Weilong Guo*#, Ping Zhu*, Matteo Pellegrini, Michael Zhang, Xiangfeng Wang, Zhongfu Ni. (2018) CGmapTools improves the precision of heterozygous SNV calls and supports allele-specific methylation detection and visualization in bisulfite-sequencing data, Bioinformatics, 34:381–387. (# Corresponding Author; * Joint First Authors)
  DOI:10.1093/bioinformatics/btx595
[Software: CGmapTools]

• (3) Weilong Guo#, Michael Zhang, Hong Wu#. (2016) Mammalian non-CG methylations are conserved and cell-type specific and may have been involved in the evolution of transposon elements, Scientific Reports, 6:32207. [GEO:GSE77019](# Corresponding Authors) ㊥ [Erratum]
  DOI:10.1038/srep32207

• (2) Weilong Guo, Wen-Yu Chung, Minping Qian, Matteo Pellegrini, Michael Q. Zhang. (2014) Characterizing the strand-specific distribution of non-CpG methylation in human pluripotent cells, Nucleic Acids Research, 42(5):3009-3016.
  DOI: 10.1093/nar/gkt1306

• (1) Weilong Guo, Petko Fiziev, Weihong Yan, Shawn Cokus, Xueguang Sun, Michael Q Zhang, Pao-Yang Chen, Matteo Pellegrini. (2013) BS-Seeker2: a versatile aligning pipeline for bisulfite sequencing data. BMC Genomics, 14(1), 774.
  DOI: 10.1186/1471-2164-14-774
[Software: BS-Seeker2]

All Publications   [top]

     2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 and before

     ★ First/Corresponding Author publications

     2023

• 66. Wenjia Zhang, Zhaoheng Zhang, Qian Chen, Zihao Wang, Wanjun Song, Kai Yang, Mingming Xin, Zhaorong Hu, Jie Liu, Huiru Peng, Jinsheng Lai, Weilong Guo, Zhongfu Ni, Qixin Sun, Jinkun Du, Yingyin Yao (2023) TMutation of a highly conserved amino acid in RPM1 causes leaf yellowing and premature senescence in wheat , Theoretical and Applied Genetics , 136(12):254.
  DOI:doi:10.1007/s00122-023-04499-4

• 65. Jianing Zhang, Zhaoheng Zhang, Ruijie Zhang, Changfeng Yang, Xiaobang Zhang, Siyuan Chang, Qian Chen, Vincenzo Rossi, Long Zhao, Jun Xiao, Mingming Xin, Jinkun Du, Weilong Guo, Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao (2023) Type I MADS-box transcription factor TaMADS-GS regulates grain size by stabilizing cytokinin signalling during endosperm cellularization in wheat , Plant Biotechnology Journal, ##(##):##-##.
  DOI:doi:10.1111/pbi.14180

• 64. Xiongtao Li, Beilu Cao, Dejie Du, Long Song, Lulu Tian, Xiaoming Xie, Zhaoyan Chen, Yanpeng Ding, Xuejiao Cheng, Yingyin Yao, Weilong Guo, Zhenqi Su, Qixin Sun, Zhongfu Ni, Lingling Chai, Jie Liu (2023) TaACTIN7-D regulates plant height and grain shape in bread wheat , Journal of Genetics and Genomics, 50(11):895-908.
  DOI:doi:10.1016/j.jgg.2023.09.001

• 63. Weiya Xu, Yongming Chen, Bin Liu, Qiuyuan Li, Yilan Zhou, Xuanshuang Li, Weilong Guo, Zhaorong Hu, Zhenshan Liu, Mingming Xin, Yingyin Yao, Mingshan You, Huiru Peng, Zhongfu Ni, Jiewen Xing (2023) TaANR1-TaMADS25 module regulates lignin biosynthesis and root development in wheat (Triticum aestivum L.) , Journal of Genetics and Genomics, 50(11):917-920.
  DOI:doi:10.1016/j.jgg.2023.08.011

• ★62. Zihao Wang, Lingfeng Miao, Yongming Chen, Huiru Peng, Zhongfu Ni, Qixin Sun, Weilong Guo #. (2023) Deciphering the evolution and complexity of wheat germplasm from a genomic perspective , Journal of Genetics and Genomics, 50(11):846-860. (# Corresponding Authors)
  DOI:doi:10.1016/j.jgg.2023.08.002
  (Review)

• ★61. Zhaoheng Zhang *, Ruijie Zhang *, Fengfan Meng, Yongming Chen, Wenxi Wang, Kai Yang, Yujiao Gao, Mingming Xin, Jinkun Du, Zhaorong Hu, Zhongfu Ni, Qixin Sun, Weilong Guo #, Yingyin Yao #. (2023) A comprehensive atlas of long non-coding RNAs provides insight into grain development in wheat , Seed Biology, 2:12. (# Corresponding Authors)
  DOI:doi:10.48130/SeedBio-2023-0012
  [Datbase: wLNCdb]

• 60. Haoran Wang, Man Feng, Yujie Jiang, Dejie Du, Chaoqun Dong, Zhaoheng Zhang, Wenxi Wang, Jing Liu, Xiangqing Liu, Sufang Li, Yongming Chen, Weilong Guo, Mingming Xin, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng, Jie Liu (2023) Thermosensitive SUMOylation of TaHsfA1 defines a dynamic ON/OFF molecular switch for the heat stress response in wheat , The Plant Cell, koad192.
  DOI:doi:10.1093/plcell/koad192

• ★59. Yongming Chen, Yiwen Guo, Xiaoming Xie, Zihao Wang, Lingfeng Miao, Zhengzhao Yang, Yuannian Jiao, Chaojie Xie, Jie Liu, Zhaorong Hu, Mingming Xin, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng #, Weilong Guo #. (2023) Pangenome-based trajectories of intracellular gene transfers in Poaceae unveil high cumulation in Triticeae , Plant Physiology, 193(1):578-594. (# Corresponding Authors)
  DOI:doi:10.1093/plphys/kiad319
  [Software: IGTminer]
  [Datbase: pNOGmap]

• ★58. Dawa Dondup *, Yang Yang *, Dongdong Xu *, Lhundrup Namgyal, Zihao Wang, Xia Shen, Tsechoe Dorji, Nyima kyi, Lhakpa Drolma, Liyun Gao, Zhuo Ga, Zha Sang, Zhuo Ga, Wang Mu, Pubu Zhuoma, Xiongnu Taba, Guocheng Jiao, Wenhua Liao, Yawei Tang, Xingquan Zeng, Zhaxi Luobu, Yufeng Wu, Chunchao Wang, Jing Zhang, Zengjun Qi #, Weilong Guo #, Ganggang Guo #. (2023) Genome diversity and highland-adaptative variation in Tibet barley landrace population of China , Frontiers in Plant Science, 14:1189642. (# Corresponding Authors; * Joint First Authors)
  DOI:doi:10.3389/fpls.2023.1189642

• 57. Long Song, Jie Liu, Beilu Cao, Bin Liu, Xiaoping Zhang, Zhaoyan Chen, Chaoqun Dong, Xiangqing Liu, Zhaoheng Zhang, Wenxi Wang, Lingling Chai, Jing Liu, Jun Zhu, Shubin Cui, Fei He, Huiru Peng, Zhaorong Hu, Zhenqi Su, Weilong Guo, Mingming Xin, Yingyin Yao, Yong Yan, Yinming Song, Guihua Bai, Qixin Sun, Zhongfu Ni. (2023) Reducing brassinosteroid signalling enhances grain yield in semi-dwarf wheat , Nature, 617(7959):118-124.
  DOI:doi:10.1038/s41586-023-06023-6

• ★56. Zhichao Yu *, Yongming Chen *, Yong Zhou *, Yulu Zhang, Mengyuan Li, Yidan Ouyang, Dmytro Chebotarov, Ramil Mauleon, Hu Zhao, Weibo Xie, Kenneth L. McNally, Rod A. Wing #, Weilong Guo #, Jianwei Zhang #. (2023) Rice Gene Index: A comprehensive pan-genome database for comparative and functional genomics of Asian rice , Molecular Plant, 16(5):798-801. (# Corresponding Authors; * Joint First Authors)
  DOI:doi:10.1016/j.molp.2023.03.012

• 55. Xiaobo Wang, Jinbo Zhang, Weiwei Mao, Panfeng Guan, Yongfa Wang, Yongming Chen, Wangqing Liu, Weilong Guo, Yingyin Yao, Zhaorong Hu, Mingming Xin, Zhongfu Ni, Qixin Sun, Huiru Peng. (2023) Association mapping identifies loci and candidate genes for grain-related traits in spring wheat in response to heat stress , Plant Science, 331:111676.
  DOI:doi:10.1016/j.plantsci.2023.111676

• 54. Wensheng Ke, Jiewen Xing, Zhaoyan Chen, Yidi Zhao, Weiya Xu, Lulu Tian, Jinquan Guo, Xiaoming Xie, Dejie Du, Zihao Wang, Yufeng Li, Jin Xu, Mingming Xin, Weilong Guo, Zhaorong Hu, Zhenqi Su, Jie Liu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni. (2023) The TaTCP4/10-B1 cascade regulates awn elongation in wheat (Triticum aestivum L.), Plant Communications, 4:100590.
  DOI:doi:10.1093/plcell/koad075

• 53. Yiwen Guo, Yongming Chen, Yongfa Wang, Xiaojia Wu, Xiaoyu Zhang, Weiwei Mao, Hongjian Yu, Kai Guo, Jin Xu, Liang Ma, Weilong Guo, Zhaorong Hu, Mingming Xin, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng. (2023) The translational landscape of bread wheat during grain development, The Plant Cell, 35(6):1848-1867.
  DOI:doi:10.1016/j.xplc.2023.100590

• 52. Guoyu Liu, Runqi Zhang, Sen Li, Rehmat Ullah, Fengping Yang, Zihao Wang, Weilong Guo, Mingshan You, Baoyun Li, Chaojie Xie, Liangsheng Wang, Jie Liu, Zhongfu Ni, Qixin Sun, Rongqi Liang. (2023) TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat, SCIENCE CHINA Life Sciences, 66(7):1647-1664.
  DOI:doi:10.1007/s11427-022-2286-0

• 51. Hongxia Liu, Xuemei Si, Zhenyu Wang, Liangjing Cao, Lifeng Gao, Xiaolong Zhou, Wenxi Wang, Ke Wang, Chengzhi Jiao, Lei Zhuang, Yunchuan Liu, Jian Hou, Tian Li, Chenyang Hao, Weilong Guo, Jun Liu, Xueyong Zhang. (2023) TaTPP-7A positively feedback regulates grain filling and wheat grain yield through T6P-SnRK1 signaling pathway and sugar-ABA interaction, Plant Biotechnology Journal, 21(6):1159-1175.
  DOI:doi:10.1111/pbi.14025

• 50. Dan Liu, Huaimao Yang, Zhaoheng Zhang, Qian Chen, Weilong Guo, Vincenzo Rossi, Mingming Xin, Jinkun Du, Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2023) An elite γ-gliadin allele improves end-use quality in wheat, New Phytologist, 239(1):87-101.
  DOI:doi:10.1111/nph.18722

• ★49. Yongming Chen *, Yiwen Guo *, Panfeng Guan, Yongfa Wang, Xiaobo Wang, Zihao Wang, Zhen Qin, Shengwei Ma, Mingming Xin, Zhaorong Hu, Yingyin Yao, Zhongfu Ni, Qixin Sun, Weilong Guo # , Huiru Peng #. (2023) A wheat integrative regulatory network from large-scale complementary functional datasets enables trait-associated gene discovery for crop improvement, Molecular Plant, 16(2):393-414. (# Corresponding Authors; * Joint First Authors)
  DOI:10.1016/j.molp.2022.12.019
  [Database: wGRN]

     2022

• 48. Mei Zheng, Jinpeng Li, Chaowu Zeng, Xingbei Liu, Wei Chu, Jingchen Lin, Fengzhi Wang, Weiwei Wang, Weilong Guo, Mingming Xin, Yingyin Yao, Huiru Peng, Zhongfu Ni, Qixin Sun, Zhaorong Hu. (2022) Subgenome-biased expression and functional diversification of a Na+/H+ antiporter homoeologs in salt tolerance of polyploid wheat, Frontiers in Plant Science, 13:1072009.
  DOI:doi:10.3389/fpls.2022.1072009

• 47. Changfeng Yang, Qian Chen, Mingming Xin, Zhenqi Su, Jinkun Du, Weilong Guo, Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2022) A highly conserved amino acid in high molecular weight glutenin subunit 1Dy12 contributes to gluten functionality and processing quality in wheat, Journal of Genetics and Genomics, 50(11):909-912.
  DOI:doi:10.1016/j.jgg.2022.11.002

• 46. Siyuan Chang, Qian Chen, Tao Yang, Binyong Li, Mingming Xin, Zhenqi Su, Jinkun Du, Weilong Guo, Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2022) Pinb-D1p is an elite allele for improving end-use quality in wheat (Triticum aestivum L.), Theoretical and Applied Genetics , 135(12):4469–4481.
  DOI:doi:10.1007/s00122-022-04232-7

• 45. Jun Xiao, Bao Liu, Yingyin Yao, Zifeng Guo, Haiyan Jia, Lingrang Kong, Aimin Zhang, Wujun Ma, Zhongfu Ni, Shengbao Xu, Fei Lu, Yuannian Jiao, Wuyun Yang, Xuelei Lin, Silong Sun, Zefu Lu, Lifeng Gao, Guangyao Zhao, Shuanghe Cao, Qian Chen, Kunpu Zhang, Mengcheng Wang, Meng Wang, Zhaorong Hu, Weilong Guo, Guoqiang Li, Xin Ma, Junming Li, Fangpu Han, Xiangdong Fu, Zhengqiang Ma, Daowen Wang, Xueyong Zhang, Hong-Qing Ling, Guangmin Xia, Yiping Tong, Zhiyong Liu, Zhonghu He, Jizeng Jia, Kang Chong. (2022) Wheat genomic study for genetic improvement of traits in China, Science China Life Sciences, 65(9):1718–1775.
  DOI:doi:10.1007/s11427-022-2178-7

• 44. Na Song, Jingchen Lin, Xingbei Liu, Zehui Liu, Debiao Liu, Wei Chu, Jinpeng Li, Yongming Chen, Shumin Chang, Qun Yang, Xiaoyu Liu, Weilong Guo, Mingming Xin, Yingyin Yao, Huiru Peng, Zhongfu Ni, Chaojie Xie, Qixin Sun, Zhaorong Hu. (2022) Histone acetyltransferase TaHAG1 interacts with TaPLATZ5 to activate TaPAD4 expression and positively contribute to powdery mildew resistance in wheat, New Phytologist, 236(2):590-607.
  DOI:doi:10.1111/nph.18372

• 43. Jingchen Lin, Na Song, Debiao Liu, Xingbei Liu, Wei Chu, Jinpeng Li, Shumin Chang, Zehui Liu, Yongming Chen, Qun Yang, Xiaoyu Liu, Yingyin Yao, Weilong Guo, Mingming Xin, Huiru Peng, Zhongfu Ni, Qixin Sun, Zhaorong Hu. (2022) Histone acetyltransferase TaHAG1 interacts with TaNACL to promote heat stress tolerance in wheat, Plant Biotechnology Journal, 20(9):1645-1647.
  DOI:doi:10.1111/pbi.13881

• ★42. Zihao Wang, Wenxi Wang, Xiaoming Xie, Yongfa Wang, Zhengzhao Yang, Huiru Peng, Mingming Xin, Yingyin Yao, Zhaorong Hu, Jie Liu, Zhenqi Su, Chaojie Xie, Baoyun Li, Zhongfu Ni, Qixin Sun #, Weilong Guo #. (2022) Dispersed emergence and protracted domestication of polyploid wheat uncovered by mosaic ancestral haploblock inference, Nature Communications, 13:3891. (# Corresponding Author; * Joint First Authors)
  DOI:doi:10.1038/s41467-022-31581-0
  [Software: IntroBlocker]
  [Behind The Paper: What makes wheat a successful major crop?]

• 41. Qian Chen, Changfeng Yang, Zhaoheng Zhang, Zihao Wang, Yongming Chen, Vincenzo Rossi, Wei Chen, Mingming Xin, Zhenqi Su, Jinkun Du, Weilong Guo, Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2022) Unprocessed wheat γ-gliadin reduces gluten accumulation associated with the endoplasmic reticulum stress and elevated cell death, New Phytologist, 236(1):146-164.
  DOI:doi:10.1111/nph.18316

• ★40. Zhengzhao Yang *, Zihao Wang *, Wenxi Wang *, Xiaoming Xie, Lingling Chai, Xiaobo Wang, Xibo Feng, Jinghui Li, Huiru Peng, Zhenqi Su, Mingshan You, Yingyin Yao, Mingming Xin, Zhaorong Hu, Jie Liu, Rongqi Liang, Zhongfu Ni, Qixin Sun, Weilong Guo #. (2022) ggComp enables dissection of germplasm resources and construction of a multiscale germplasm network in wheat, Plant Physiology, 188(4):1950-1965. (# Corresponding Author; * Joint First Authors)
  DOI:doi:10.1093/plphys/kiac029
  [Software: ggComp]
  [Database: WheatCompDB]

• 39. Lingling Chai, Mingming Xin, Chaoqun Dong, Zhaoyan Chen, Huijie Zhai, Junhong Zhuang, Xuejiao Cheng, Naijiao Wang, Jia Geng, Xiaobo Wang, Ruolin Bian, Yingyin Yao, Weilong Guo, Zhaorong Hu, Huiru Peng, Guihua Bai, Qixin Sun, Zhenqi Su, Jie Liu, Zhongfu Ni. (2022) A natural variation in Ribonuclease H-like gene underlies Rht8 to confer “Green Revolution” trait in wheat, Molecular Plant, 15(3):377-380.
  DOI:10.1016/j.molp.2022.01.013

• 38. Zhaoyan Chen, Wensheng Ke, Fei He, Lingling Chai, Xuejiao Cheng, Huanwen Xu, Xiaobo Wang, Dejie Du, Yidi Zhao, Xiyong Chen, Jiewen Xing, Mingming Xin, Weilong Guo, Zhaorong Hu, Zhenqi Su, Jie Liu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni. (2022) A single nucleotide deletion in the third exon of FT-D1 increases the spikelet number and delays heading date in wheat (Triticum aestivum L.), Plant Biotechnology Journal, 20(5):920-933.
  DOI:10.1111/PBI.13773

     2021

• 37. Shengwei Ma, Meng Wang, Jianhui Wu, Weilong Guo, Yongming Chen, Guangwei Li, Yanpeng Wang, Weiming Shi, Guangmin Xia, Daolin Fu, Zhensheng Kang, Fei Ni. (2021) WheatOmics: A platform combining multiple omics data to accelerate functional genomics studies in wheat, Molecular Plant, 14(12):1965-1968.
  DOI:10.1016/j.molp.2021.10.006
  [Database: WheatOmics]

• 36. Zhiyu Feng, Long Song, Wanjun Song, Zhongqi Qi, Jun Yuan, Run Li, Haiming Han, Huifang Wang, Zhaoyan Chen, Weilong Guo, Mingming Xin, Jie Liu, Zhaorong Hu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni, Jiewen Xing. (2021) The decreased expression of GW2 homologous genes contributed to the increased grain width and thousand‑grain weight in wheat-Dasypyrum villosum 6VS·6DL translocation lines, Theoretical and Applied Genetics, 134(12):3873-3894.
  DOI:10.1007/s00122-021-03934-8

• 35. Xiang Gao, Weipeng Mo, Junpeng Shi, Ning Song, Pei Liang, Jian Chen, Yiting Shi, Weilong Guo, Xinchen Li, Xiaohong Yang, Beibei Xin, Haiming Zhao, Weibin Song, Jinsheng Lai. (2021) HITAC-seq enables high-throughput cost-effective sequencing of plasmids and DNA fragments with identity-tracked, Journal of Genetics and Genomics , 48(8):671-680.
  DOI:d10.1016/j.jgg.2021.05.009

• 34. Qiang Zhang, Wenxin Wei, Xiangxi Zuansun, Shengnan Zhang, Chen Wang, Nannan Liu, Lina Qiu, Weidong Wang, Weilong Guo, Jun Ma, Huiru Peng, Zhaorong Hu, Qixin Sun, Chaojie Xie. (2021) Fine Mapping of the Leaf Rust Resistance Gene Lr65 in Spelt Wheat ‘Altgold’, Frontiers in Plant Science, 12:666921.
  DOI:10.3389/fpls.2021.666921

• 33. Lina Qiu, Nannan Liu, Huifang Wang, Xiaohan Shi, Feng Li, Qiang Zhang, Weidong Wang, Weilong Guo, Zhaorong Hu, Hongjie Li, Jun Ma, Qixin Sun, Chaojie Xie. (2021) Fine mapping of a powdery mildew resistance gene MlIW39 derived from wild emmer wheat (Triticum turgidum ssp. dicoccoides), Theoretical and Applied Genetics , 134(8):2469-2479.
  DOI:10.1007/s00122-021-03836-9

• 32. Jing Liu, Zhaoyan Chen, Zhihui Wang, Zhaoheng Zhang, Xiaoming Xie, Zihao Wang, Lingling Chai, Long Song, Xuejiao Cheng, Man Feng, Xiaobo Wang, Yanhong Liu, Zhaorong Hu, Jiewen Xing, Zhenqi Su, Huiru Peng, Mingming Xin, Yingyin Yao, Weilong Guo, Qixin Sun, Jie Liu, Zhongfu Ni. (2021) Ectopic expression of VRT-A2 underlies the origin of Triticum polonicum and Triticum petropavlovskyi with long outer glumes and grains, Molecular Plant , 14(9):1472-1488.
  DOI:10.1016/j.molp.2021.05.021

• 31. Dejie Du, Dongxue Zhang, Jun Yuan, Man Feng, Zhaoju Li, Zihao Wang, Zhaoheng Zhang, Xiongtao Li, Wensheng Ke, Renhan Li, Zhaoyan Chen, Lingling Chai, Zhaorong Hu, Weilong Guo, Jiewen Xing, Zhenqi Su, Huiru Peng, Mingming Xin, Yingyin Yao, Qixin Sun, Jie Liu, Zhongfu Ni. (2021) New Phytologist, FRIZZY PANICLE defines a regulatory hub for simultaneously controlling spikelet formation and awn elongation in bread wheat , 231(2):814-833.
  DOI:10.1111/nph.17388

• 30. Linghong Li, Lingling Chai, Huanwen Xu, Huijie Zhai, Tianya Wang, Mingyi Zhang, Mingshan You, Huiru Peng, Yingyin Yao, Zhaorong Hu, Mingming Xin, Weilong Guo, Qixin Sun, Xiyong Chen, Zhongfu Ni. (2021) Phenotypic characterization of the glossy1 mutant and fine mapping of GLOSSY1 in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics , 134(3):835-847.
  DOI:10.1007/s00122-020-03734-6

• 29. Yujiao Gao, Kexin An, Weiwei Guo, Yongming Chen, Ruijie Zhang, Xue Zhang, Siyuan Chang, Vincenzo Rossi, Fangming Jin, Xinyou Cao, Mingming Xin, Huiru Peng, Zhaorong Hu, Weilong Guo, Jinkun Du, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2021) The endosperm-specific transcription factor TaNAC019 regulates glutenin and starch accumulation and its elite allele improves wheat grain quality, The Plant Cell , 33(3):603-622.
  DOI:10.1093/plcell/koaa040

     2020

• 28. Kuohai Yu, Man Feng, Guanghui Yang, Lv Sun, Zhen Qin, Jie Cao, Jingjing Wen, Haoran Li, Yan Zhou, Xiangping Chen, Huiru Peng, Yingyin Yao, Zhaorong Hu, Weilong Guo , Qixin Sun, Zhongfu Ni, Keith Adams, Mingming Xin. (2020) Changes in Alternative Splicing in Response to Domestication and Polyploidization in Wheat, Plant Physiology , 184(4):1955-1968.
  DOI:10.1104/pp.20.00773

• ★27. Yongming Chen, Wanjun Song, Xiaoming Xie, Zihao Wang, Panfeng Guan, Huiru Peng, Yuannian Jiao, Zhongfu Ni, Qixin Sun, Weilong Guo #. (2020) A Collinearity-incorporating Homology Inference Strategy for Connecting Emerging Assemblies in Triticeae Tribe as a Pilot Practice in the Plant Pangenomic Era, Molecular Plant , 13(12):1694-1708. (# Corresponding Author)
  DOI:doi:10.1016/j.molp.2020.09.019
  [Featured Article: (On The Cover) ]
  [Software: GeneTribe]
  [Database: Triticeae-GeneTribe / TGT]

• ★26. Weilong Guo *, Mingming Xin *, Zihao Wang *, Yingyin Yao, Zhaorong Hu, Wanjun Song, Kuohai Yu, Yongming Chen, Xiaobo Wang, Panfeng Guan, Rudi Appels, Huiru Peng #, Zhongfu Ni #, Qixin Sun #. (2020) Origin and adaptation to high altitude of Tibetan semi-wild wheat, Nature Communications , 11:5085. (# Corresponding Authors; * Joint First Authors)
  DOI:10.1038/s41467-020-18738-5
  [Resource Homepage: Zang817_Genome]
  [SnpHub server: SnpHub-NC20]

• ★25. Wenxi Wang *, Zihao Wang *, Xintong Li, Zhongfu Ni, Zhaorong Hu, Mingming Xin, Huiru Peng, Yingyin Yao, Qixin Sun, Weilong Guo #. (2020) SnpHub: an easy-to-set-up web server framework for exploring large-scale genomic variation data in the post-genomic era with applications in wheat, GigaScience , 9(6):giaa060. (# Corresponding Author; * Joint First Authors)
  DOI:10.1093/gigascience/giaa060
  [Software: SnpHub]
  [Servers: Wheat-SnpHub-Portal]

• 24. Lina Qiu, Huifang Wang, Yinghui Li, Weidong Wang, Yujia Liu, Junyi Mu, Miaomiao Geng, Weilong Guo, Zhaorong Hu, Jun Ma, Qixin Sun, Chaojie Xie. (2020) Fine Mapping of the Wheat Leaf Rust Resistance Gene LrLC10 (Lr13) and Validation of Its Co-segregation Markers, Frontiers in Plant Science, 11:470.
  DOI:10.3389/fpls.2020.00470

• 23. Feng Huang, Zhaoyan Chen, Dejie Du, Panfeng Guan, Lingling Chai, Weilong Guo, Zhaorong Hu, Mingming Xin, Huiru Peng, Yingyin Yao, Zhongfu Ni. (2020) Genome-wide linkage mapping of QTL for root hair length in a Chinese common wheat population, The Crop Journal , 8(6):1049-1056.
  DOI:10.1016/j.cj.2020.02.007

• 22. Jinghui Li, Shaozhe Wen, Chaofeng Fan, Minghu Zhang, Shuai Tian, Wenjing Kang, Wenxin Zhao, Chan Bi, Qiuyan Wang, Shuang Lu, Weilong Guo, Zhongfu Ni, Chaojie Xie, Qixin Sun, Mingshan You. (2020) Characterization of a major quantitative trait locus on the short arm of chromosome 4B for spike number per unit area in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics , 133(7):2259-2269.
  DOI:10.1007/s00122-020-03595-z

• 21. Xuejiao Cheng, Mingming Xin, Ruibin Xu, Zhaoyan Chen, Wenlong Cai, Lingling Chai, Huanwen Xu, Lin Jia, Zhiyu Feng, Zihao Wang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Weilong Guo, Zhongfu Ni, Qixin Sun. (2020) A Single Amino Acid Substitution in STKc_GSK3 Kinase Conferring Semispherical Grains and Its Implications for the Origin of Triticum sphaerococcum, The Plant Cell, 32(4):923-934.
  DOI:10.1105/tpc.19.00580

• 20. Zhaoyan Chen, Xuejiao Cheng, Lingling Chai, Zihao Wang, Dejie Du, Zhihui Wang, Ruolin Bian, Aiju Zhao, Mingming Xin, Weilong Guo, Zhaorong Hu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni. (2020) Pleiotropic QTL influencing spikelet number and heading date in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics , 133(6):1825–1838.
  DOI:10.1007/s00122-020-03556-6

• 19. Linghong Li, Zhongqi Qi, Lingling Chai, Zhaoyan Chen, Tianya Wang, Mingyi Zhang, Mingshan You, Huiru Peng, Yingyin Yao, Zhaorong Hu, Mingming Xin, Weilong Guo, Qixin Sun, Zhongfu Ni. (2020) The semidominant mutation w5 impairs epicuticular wax deposition in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 133(4):1213–1225.
  DOI:10.1007/s00122-020-03543-x

• 18. Zhaoyan Chen, Xuejiao Cheng, Lingling Chai, Zhihui Wang, Ruolin Bian, Jiang Li, Aiju Zhao, Mingming Xin, Weilong Guo, Zhaorong Hu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni. (2020) Dissection of genetic factors underlying grain size and fine mapping of QTgw.cau‐7D in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 133(6)1825–1838.
  DOI:10.1007/s00122-019-03447-5

     2019

• 17. Kaiye Liu, Jie Cao, Kuohai Yu, Xinye Liu, Yujiao Gao, Qian Chen, Wenjia Zhang, Huiru Peng, Jinkun Du, Mingming Xin, Zhaorong Hu, Weilong Guo, Vincenzo Rossi, Zhongfu Ni, Qixin Sun, and Yingyin Yao. (2019) Wheat TaSPL8 Modulates Leaf Angle Through Auxin and Brassinosteroid Signaling, Plant Physiology, 181(1)179–194.
  DOI:10.1104/pp.19.00248

• 16. Ning Zhang, Jing Xu, Xinye Liu, Wenxing Liang, Mingming Xin, Jinkun Du, Zhaorong Hu, Huiru Peng, Weilong Guo, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2019) Identification of HSP90C as a substrate of E3 ligase TaSAP5 through ubiquitylome profiling, Plant Science, 287, 110170.
  DOI:10.1016/j.plantsci.2019.110170

• 15. Panfeng Guan, Na Di, Qing Mu, Xueyi Shen, Yongfa Wang, Xiaobo Wang, Kuohai Yu, Wanjun Song, Yongming Chen, Mingming Xin, Zhaorong Hu, Weilong Guo, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng. (2019) Use of near-isogenic lines to precisely map and validate a major QTL for grain weight on chromosome 4AL in bread wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 132, 2367–2379.
  DOI:10.1007/s00122-019-03359-4

• 14. Peng Wu, Yan Gao, Weilong Guo, Ping Zhu. (2019) Using Local Alignment to Enhance Single Cell Bisulfite Sequencing Data Efficiency, Bioinformatics, 35(18):3273–3278.
  DOI:10.1093/bioinformatics/btz125
[Software: scBS-map]

     2018

• 13. Haichuan Zhu, Liuzhen Zhang, Yilin Wu, Bingjie Dong, Weilong Guo, Mei Wang, Lu Yang, Xiaoying Fan, Yuliang Tang, Ningshu Liu, Xiaoguang Lei, Hong Wu. (2018) T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1,eLife, 7:e38314.
  DOI:10.7554/elife.38314

• 12. Lingling Chai, Zhaoyan Chen, Ruolin Bian, Huijie Zhai, Xuejiao Cheng, Huiru Peng, Yingyin Yao, Zhaorong Hu, Mingming Xin, Weilong Guo, Qixin Sun, Aiju Zhao, Zhongfu Ni. (2018) Dissection of two quantitative trait loci with pleiotropic effects on plant height and spike length linked in coupling phase on the short arm of chromosome 2D of common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 131(12):2621–2637.
  DOI:10.1007/s00122-018-3177-4

• 11. Yongkang Zou, Zhi Qi, Weilong Guo, Liuzhen Zhang, Marcus Ruscetti, Tanu Shenoy, Ningshu Liu, Hong Wu. (2018) Cotargeting the Cell-Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ Inhibitor BAY1082439., Molecular Cancer Therapeutics, 17(10):2091-2099.
  DOI:10.1158/1535-7163.MCT-18-0038

• ★10. Weilong Guo *#, Ping Zhu*, Matteo Pellegrini, Michael Zhang, Xiangfeng Wang, Zhongfu Ni. (2018) CGmapTools improves the precision of heterozygous SNV calls and supports allele-specific methylation detection and visualization in bisulfite-sequencing data, Bioinformatics, 34:381–387. (# Corresponding Author; * Joint First Authors)
  DOI:10.1093/bioinformatics/btx595
[Software: CGmapTools]

     2017 and before

• 09. Shenoy TR, Boysen G, Wang MY, Xu QZ, Guo W, Koh FM, Wang C, Zhang LZ, Wang Y, Gil V, et al., Aziz S, Christova R, Rodrigues DN, Crespo M, Rescigno P, Tunariu N, Riisnaes R, Zafeiriou Z, Flohr P, Yuan W, Knight E, Swain A, Ramalho-Santos M, Xu DY, de Bono J, Wu H. (2017) CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair, Annals of Oncology , 28(7)1495–1507. [GSE84610]
  DOI:10.1093/annonc/mdx165

• ★08. Weilong Guo #, Michael Zhang, Hong Wu#. (2016) Mammalian non-CG methylations are conserved and cell-type specific and may have been involved in the evolution of transposon elements, Scientific Reports, 6:32207. [GEO:GSE77019](# Corresponding Authors) ㊥ [Erratum]
  DOI:10.1038/srep32207

• 07. Qingying Meng, Zhe Ying, Emily Noble, Yuqi Zhao, Rahul Agrawal, Andrew Mikhail, Yumei Zhuang, Ethika Tyagi, Qing Zhang, Jae-Hyung Lee, Marco Morselli, Luz Orozco, Weilong Guo, Tina M. Kilts, Jun Zhu, Bin Zhang, Matteo Pellegrini, Xinshu Xiao, Marian F. Young, Fernando Gomez-Pinilla, Xia Yang. (2016) Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders, EBioMedicine, 7:157-166.
  DOI:10.1016/j.ebiom.2016.04.008

• 06. Marcus Ruscetti, Eman L. Dadashian, Weilong Guo, Bill Quach, David J. Mulholland, Juw W. Park, Linh M. Tran, Naoko Kobayashi, Daniella Bianchi-Frias, Peter S. Nelson, Yi Xing, and Hong Wu. (2015) HDAC Inhibition Impedes HMGA2-controlled Epithelial-Mesenchymal Plasticity and Suppresses Metastatic, Castration-Resistant Prostate Cancer, Oncogene, 35(29),1-15.
  DOI:10.1038/onc.2015.444

• 05. Luz D Orozco, Marco Morselli, Liudmilla Rubbi, Weilong Guo, James Go, Huwenbo Shi, David Lopez, Nicholas A Furlotte, Brian J Bennett, Charles R Farber, Anatole Ghazalpour, Michael Q Zhang, Renata Bahous, Rima Rozen, Aldons J Lusis, Matteo Pellegrini. (2015) Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice, Cell Metabolism,21(6):905-917.
  DOI: 10.1016/j.cmet.2015.04.025
  

• 04. Yun Li, Jason A. Chen, Renee L. Sears, Fuying Gao, Eric D. Klein, Anna Karydas, Michael D. Geschwind, Howard J. Rosen, Adam L. Boxer, Weilong Guo, Matteo Pellegrini, Steve Horvath, Bruce L. Miller, Daniel H. Geschwind, Giovanni Coppol. (2014) An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy, PLoS Genetics, 10(3):e1004211.
  DOI: 10.1371/journal.pgen.1004211

• ★03. Weilong Guo, Wen-Yu Chung, Minping Qian, Matteo Pellegrini, Michael Q. Zhang. (2014) Characterizing the strand-specific distribution of non-CpG methylation in human pluripotent cells, Nucleic Acids Research, 42(5):3009-3016.
  DOI: 10.1093/nar/gkt1306

• ★02. Weilong Guo, Petko Fiziev, Weihong Yan, Shawn Cokus, Xueguang Sun, Michael Q Zhang, Pao-Yang Chen, Matteo Pellegrini. (2013) BS-Seeker2: a versatile aligning pipeline for bisulfite sequencing data, BMC Genomics, 14(1):774.
  DOI: 10.1186/1471-2164-14-774
[Software: BS-Seeker2]

• 01. Ruijuan Li, Weilong Guo, Jin Gu, Michael Q. Zhang, Xiaowo Wang. (2012) Chromatin state and microRNA determine different gene expression dynamics responsive to TNF stimulation, Genomics, 100(5):297-302.
  DOI: 10.1016/j.ygeno.2012.07.009

Academical Sevice   [top]

Invited Reviewer

• Molecular Plant
• Plant Biotechnology Journal
• Plant Communications
• Cell Report
• Journal of Genetics and Genomics
• Crop Journal
• Frointiers in Plant Science
• Journal of Intergrative Agriculture
• BMC Genomics
• PLoS ONE
• BMC Bioinformatics
• Quantitative Biology
• Computational and Structural Biotechnology Journal